| People involved: | Ebbe Nordlander |
| Former members: | Lotta Glans |
This project is related to the following Fields, Subjects and Techniques:
| Fields: | Synthetic Chemistry, Medicinal Chemistry |
| Subjects: | Metal Complexes |
| Techniques: | Inorganic and organic synthesis |
Every year there is an estimated 300-500 clinical cases of malaria and the disease causes 1.5-2.7 million deaths. In addition, malaria parasites have developed a resistance to the most common anti-malarials. This is especially severe in the case of chloroquine, which is a relatively cheap and safe drug. However, organometallic versions of chloroquine have shown promising activity against resistant parasites.
We are studying organometallic chloroquine derivatives, initially based on chromium. Novel half-sandwich chromium complexes with a connected chloroquine moiety are under preparation. Such chromium complexes are analogous to sandwich complexes like ferroquine3, which has shown strong anti-malarial activity. In vitro tests of their antimalarial activity will be carried out. At a later stage other chloroquine derivatives will be synthesised.
