A pyrazine amide – 4-aminoquinoline hybrid and its rhodium and iridium pentamethylcyclopentadienyl complexes; evaluation of anti-mycobacterial and anti-plasmodial activities

Summary, in English

The synthesis and characterization of N-(2-((7-chloroquino-lin-4-yl)amino)ethyl)pyrazine-2-carboxamide (L), an aminoquinoline – pyrazinamide hybrid, and the complexes (N-(2-((7-chloroquino-lin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl) chlorido-rhodium or iridium hexafluorophosphate ([M(L)(Cp*)Cl] PF₆; M = Rh, Ir) and the corresponding chlorido salts ([M(L)(Cp*) Cl]Cl; M = Rh, Ir) are described. The ligand and the hexafluorophosphate salts of the metal complexes have been evaluated for anti-plasmodial and anti-mycobacterial activity. The rhodium and the iridium complexes were significantly more active against M. tuberculosis than the free ligand. The crystallographically determined molecular structures of complexes (N-(2-((7-chloroquinolin-4-yl)amino)ethyl) pyrazine-2-carboxamide)(cyclopentadienyl) chlororhodium hexafluoro-phosphate and (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyr-azine-2-carboxamide)(cyclopentadienyl)chloro-iridium chloride are presented.

• Author: Erik Ekengard; Ida Bergare; Isa Doverbratt; Magda Monari; Bhavna Gordhan; Bavesh Kana; Carmen de Kock; Peter J Smith; Ebbe Nordlander; Josefine Hansson
• Department/s: Chemical Physics; Centre for Analysis and Synthesis
• Publishing year: 2017-04-01
• Language: English
• Pages: 158-166
• Publication/Series: Journal of the Mexican Chemical Society
• Volume: 61
• Issue: 2
• Document type: Journal article
• Publisher: Sociedad Quimica de Mexico A.C.
• Topic: Organic Chemistry
• Keywords: Chloroquine; Half-sandwich; Malaria; Organometallic; Pyrazinamide; Tuberculosis
• Status: Published
• ISBN/ISSN/Other: ISSN: 1870-249X