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Ebbe Nordlander. Portrait.

Ebbe Nordlander

Professor

Ebbe Nordlander. Portrait.

The influence of thioether-substituted ligands in dicopper(II) complexes : Enhancing oxidation and biological activities

Author

  • Daniele C. Durigon
  • Vinícius A. Glitz
  • Beatriz F. Pimenta
  • Anderson M.V. Guedes
  • João V.O. Silva
  • Catarina C. Bella Cruz
  • Lídia M. Andrade
  • Elene C. Pereira-Maia
  • Jane M.G. Mikcha
  • Alexandre Bella Cruz
  • Fernando R. Xavier
  • Hernán F. Terenzi
  • Giordano Poneti
  • Ronny R. Ribeiro
  • Ebbe Nordlander
  • Giovanni F. Caramori
  • Adailton J. Bortoluzzi
  • Rosely A. Peralta
Show all

Summary, in English

This paper describes the synthesis, structural analysis, as well as the magnetic and spectroscopic characterizations of three new dicopper(II) complexes with dinucleating phenol-based ligands containing different thioether donor substituents: aromatic (1), aliphatic (2) or thiophene (3). Temperature-dependent magnetometry reveals the presence of antiferromagnetic coupling for 1 and 3 (J = −2.27 cm−1 and -5.01 cm−1, respectively, H = -2JS1S2) and ferromagnetic coupling for 2 (J = 5.72 cm−1). Broken symmetry DFT calculations attribute this behavior to a major contribution from the dz2 orbitals for 1 and 3, and from the dx2-y2 orbitals for 2, along with the p orbitals of the oxygens. The bioinspired catalytic activities of these complexes related to catechol oxidase were studied using 3,5-di-tert-butylcatechol as substrate. The order of catalytic rates for the substrate oxidation follows the trend 1 > 2 > 3 with kcat of (90.79 ± 2.90) × 10−3 for 1, (64.21 ± 0.99) × 10−3 for 2 and (14.20 ± 0.32) × 10−3 s−1 for 3. The complexes also cleave DNA through an oxidative mechanism with minor-groove preference, as indicated by experimental and molecular docking assays. Antimicrobial potential of these highly active complexes has shown that 3 inhibits both Staphylococcus aureus bacterium and Epidermophyton floccosum fungus. Notably, the complexes were found to be nontoxic to normal cells but exhibited cytotoxicity against epidermoid carcinoma cells, surpassing the activity of the metallodrug cisplatin. This research shows the multifaceted properties of these complexes, making them promising candidates for various applications in catalysis, nucleic acids research, and antimicrobial activities.

Department/s

  • LU Profile Area: Light and Materials
  • Chemical Physics

Publishing year

2024-07

Language

English

Publication/Series

Journal of Inorganic Biochemistry

Volume

256

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences
  • Physical Chemistry (including Surface- and Colloid Chemistry)
  • Inorganic Chemistry
  • Organic Chemistry

Keywords

  • Anticancer activity
  • Antimicrobial activity
  • Catecholase Activity
  • Dicopper(II) complexes
  • DNA cleavage
  • Thioether ligands

Status

Published

ISBN/ISSN/Other

  • ISSN: 0162-0134