Synthesis and characterization of Fe^III(μ-OH)Zn^II complexes : Effects of a second coordination sphere and increase in the chelate ring size on the hydrolysis of a phosphate diester and DNA

Summary, in English

The synthesis and characterization of three ligands and their respective heterobinuclear Fe^IIIZn^II complexes were carried out, with the goal of mimicking the active site of purple acid phosphatases (PAPs). The ligand 2-hydroxy-3-(((2-hydroxy-5-methyl-3-(((2-(pyridin-2-yl)ethyl)(pyridin-2-ylmethyl)amino)methyl)benzyl)(pyridin-2ylmethyl)amino)methyl)-5-methylbenzaldehyde (H₂L²) was synthesized and its complex (Fe^IIIZn^IIL²) was used as a basis for comparison with similar complexes previously published in the literature. Subsequent modifications were conducted in the aldehyde group, where 1,2-ethanediamine and 1,4-diaminobutane were used as side chain derivatives. The compounds Fe^IIIZn^IIL² (1), Fe^IIIZn^IIL²-et (2) and Fe^IIIZn^IIL²-but (3) were characterized by spectroscopic methods (infrared and UV-Vis) and ESI-MS spectrometry. Theoretical calculations were performed to provide insights into the complex structures with Fe^IIIZn^II structures. The hydrolytic activity was analyzed both with the model substrate 2,4-BDNPP and with DNA catalyzed by complexes 1, 2 and 3.

• Author: Graciela Aparecida Dos Santos Silva; André Luiz Amorim; Bernardo De Souza; Philipe Gabriel; Hernán Terenzi; Ebbe Nordlander; Ademir Neves; Rosely A. Peralta
• Department/s: Chemical Physics
• Publishing year: 2017
• Language: English
• Pages: 11380-11394
• Publication/Series: Dalton Transactions
• Volume: 46
• Issue: 34
• Links: http://dx.doi.org/10.1039/c7dt02035j
• Document type: Journal article
• Publisher: Royal Society of Chemistry
• Topic: Inorganic Chemistry
• Status: Published
• ISBN/ISSN/Other: ISSN: 1477-9226